Search results for " Uterine"

showing 10 items of 61 documents

Could lymphadenectomy be avoided in locally advanced cervical cancer patients administered preoperative chemoradiation? A large-scale retrospective s…

2017

Abstract Introduction To identify a subset of cervical cancer (CC) patients administered chemoradiation (CT/RT) plus radical surgery (RS), who can be spared lymphadenectomy, and complications. Patients and methods 430 Stage IB2-IIB patients without LN involvement at imaging were accrued (March 1996–December 2015) at Gynecologic Oncology Unit of the Catholic University of Rome/Campobasso. CT/RT consisted of pelvic irradiation plus cisplatin based chemotherapy. Objective response was evaluated according to RECIST criteria; radical hysterectomy and pelvic ± aortic lymphadenectomy was attempted in patients achieving response or stable disease. Surgical morbidity was classified according to the …

0301 basic medicineComplicationsmedicine.medical_treatmentRadical surgeryUterine Cervical Neoplasms0302 clinical medicineCervical cancer Chemoradiation Aged 80 and over Antineoplastic Agents Cisplatin Combined Modality Therapy Female Humans Hysterectomy Middle Aged Neoplasm Staging Retrospective Studies Treatment Outcome Uterine Cervical Neoplasms Chemoradiotherapy Lymph Node Excision Lymphadenectomy Radical surgery80 and overMedicineStage (cooking)Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIAAged 80 and overCervical cancerChemoradiotherapyGeneral MedicineMiddle AgedCombined Modality TherapyLymphovascularTreatment Outcomemedicine.anatomical_structureChemoradiationOncologyCervical cancer; Chemoradiation; Complications; Lymphadenectomy; Radical surgery; Adult; Aged; Aged 80 and over; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Female; Humans; Hysterectomy; Middle Aged; Neoplasm Staging; Retrospective Studies; Treatment Outcome; Uterine Cervical Neoplasms; Chemoradiotherapy; Lymph Node Excision; Surgery; Oncology030220 oncology & carcinogenesisFemaleAdultmedicine.medical_specialtyAntineoplastic AgentsGynecologic oncologyHysterectomy03 medical and health sciencesHumansRadical surgeryRadical HysterectomyCervixAgedNeoplasm StagingRetrospective Studiesbusiness.industryLymphadenectomymedicine.diseaseSurgery030104 developmental biologyCervical cancerLymph Node ExcisionSurgeryLymphadenectomyCervical cancer; Chemoradiation; Complications; Lymphadenectomy; Radical surgery; Adult; Aged; Aged 80 and over; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Female; Humans; Hysterectomy; Middle Aged; Neoplasm Staging; Retrospective Studies; Treatment Outcome; Uterine Cervical Neoplasms; Chemoradiotherapy; Lymph Node ExcisionCisplatinbusinessEuropean Journal of Surgical Oncology
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Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives

2017

Carcinosarcomas (CS) in gynecology are very infrequent and represent only 2–5% of uterine cancers. Despite surgical cytoreduction and subsequent chemotherapy being the primary treatment for uterine CS, the overall five-year survival rate is 30 ± 9% and recurrence is extremely common (50–80%). Due to the poor prognosis of CS, new strategies have been developed in the last few decades, targeting known dysfunctional molecular pathways for immunotherapy. In this paper, we aimed to gather the available evidence on the latest therapies for the treatment of CS. We performed a systematic review using the terms “uterine carcinosarcoma”, “uterine Malignant Mixed Müllerian Tumors”, “target therapies”,…

0301 basic medicineOncologyPathologyAngiogenesisCarcinosarcomas epigenetics genetics immunotherapy uterine cancer.medicine.medical_treatmentReviewEpigenesis Geneticlcsh:Chemistry0302 clinical medicineCarcinosarcomaAntibodies BispecificCarcinosarcomas Epigenetics Genetics Immunotherapy Uterine cancerMedicinegeneticsMolecular Targeted Therapylcsh:QH301-705.5Human Epidermal Growth Factor Receptor 2SpectroscopyNeovascularization PathologicGeneral MedicineEpithelial Cell Adhesion MoleculePrognosisComputer Science ApplicationsErbB ReceptorsSurvival Rate030220 oncology & carcinogenesisUterine NeoplasmsFemaleImmunotherapymedicine.medical_specialtyPoor prognosisMixed Tumor MullerianCatalysisuterine cancerInorganic Chemistry03 medical and health sciencesCancer stem cellInternal medicineBiomarkers TumorHumansTarget therapyPhysical and Theoretical ChemistrycarcinosarcomasMolecular BiologySurvival rateChemotherapyepigeneticsbusiness.industryOrganic ChemistryImmunotherapy030104 developmental biologylcsh:Biology (General)lcsh:QD1-999businessInternational Journal of Molecular Sciences
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Alcohol consumption and risk of uterine myoma: A systematic review and meta analysis

2017

Background The published data about alcohol consumption and uterine myoma are scanty and controversial: some studies found positive association whereas other studies showed no association. Objectives To conduct a systematic review and meta-analysis to determine whether alcohol is a risk factor for myoma. Search strategy A MEDLINE/EMBASE search was carried out, supplemented by manual searches of bibliographies of the selected studies. Selection criteria Articles published as full-length papers in English. In the review we included all identified studies. Otherwise, the inclusion criteria for studies included in the meta-analysis were: a) case-control or cohort studies, reporting original dat…

Adult Alcohol Drinking Female Humans Middle Aged Myoma Odds Ratio Risk Factors Uterine Neoplasms Young Adultlcsh:MedicineSocial SciencesBiochemistryCohort StudiesMathematical and Statistical Techniques0302 clinical medicineRisk FactorsOdds RatioMedicine and Health SciencesPsychologyMedicinePublic and Occupational Health030212 general & internal medicinelcsh:Scienceeducation.field_of_studyAlcohol Consumption030219 obstetrics & reproductive medicineMultidisciplinaryObstetricsAlcoholic BeveragesBeerMiddle AgedResearch AssessmentAlcoholismSystematic reviewResearch DesignMeta-analysisUterine NeoplasmsPhysical SciencesFemaleStatistics (Mathematics)Research ArticleCohort studyAdultmedicine.medical_specialtyAlcohol DrinkingSystematic ReviewsSubstance-Related DisordersPopulationAddictionSubgroup analysisResearch and Analysis MethodsBeveragesYoung Adult03 medical and health sciencesMental Health and PsychiatryHumansStatistical MethodsRisk factoreducationNutritionbusiness.industrylcsh:RBiology and Life SciencesEstrogensMyomaOdds ratiomedicine.diseaseMyomaHormonesDietlcsh:QbusinessMathematicsMeta-AnalysisPLOS ONE
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Can We Define the Risk of Lymph Node Metastasis in Early-Stage Cervical Cancer Patients? A Large-Scale, Retrospective Study

2017

BACKGROUND: Sentinel lymph node (SLN) biopsy has emerged as one of the most appreciated techniques for reducing the rate of complete lymph node dissection (LND) performed in patients with early-stage cervical cancer (ECC). However, its performances are still a matter of debate and, to improve them, international guidelines recommend performing at least unilateral LND in case of SLN mapping. In a prior study, we identified a group of patients without evidence of lymph node metastasis (LNM). Our objective is to define a precise risk of LNM for each ECC patient in order to significantly tailor surgery for ECC. METHODS: Clinical and pathological data of ECC patients were retrospectively collect…

AdultAdenocarcinoma; Adult; Aged; Aged 80 and over; Carcinoma Squamous Cell; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Uterine Cervical Neoplasms; Young Adult; Lymph Node Excision; Sentinel Lymph Node Biopsy0301 basic medicinemedicine.medical_specialtySentinel lymph nodeUterine Cervical NeoplasmsAdenocarcinomaLogistic regressionYoung Adult03 medical and health sciences0302 clinical medicineRisk FactorsmedicineHumansStage (cooking)Large-Scale Retrospective Study Sentinel lymph node (SLN) biopsy Lymphadenectomy (LND) early-stage cervical cancer (ECC)Lymph nodeAgedRetrospective StudiesAged 80 and overCervical cancerSentinel Lymph Node Biopsybusiness.industryRetrospective cohort studyMiddle AgedPrognosismedicine.diseaseSurgerySurvival Ratecervical cancer lymph nodes metastasesDissectionExact testSettore MED/40 - GINECOLOGIA E OSTETRICIA030104 developmental biologymedicine.anatomical_structureOncologyLymphatic Metastasis030220 oncology & carcinogenesisSurgery; OncologyCarcinoma Squamous CellLymph Node ExcisionFemaleSurgeryRadiologybusinessFollow-Up StudiesAnnals of Surgical Oncology
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Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma.

2022

Objective To evaluate the effect of inhibition of histone deacetylases (HDACs) by suberoylanilide hydroxamic acid (SAHA) treatment of human uterine leiomyoma primary (HULP) cells in vitro on cell proliferation, cell cycle, extracellular matrix (ECM) formation, and transforming growth factor β3 (TGF-β3) signaling. Design Prospective study comparing uterine leiomyoma (UL) vs. adjacent myometrium (MM) tissue and cells with or without SAHA treatment. Setting Hospital and university laboratories. Patient(s) Women with UL without any hormone treatment. Intervention(s) Myomectomy or hysterectomy surgery in women for leiomyoma disease. Main Outcome Measure(s) HDAC activity was assessed by enzyme-li…

AdultAntineoplastic AgentsHistone Deacetylase 1MMP9Histone Deacetylase 6Histone DeacetylasesCyclin D1Transforming Growth Factor beta3Cell proliferation SAHA ULS-ß3 pathway extracellular matrix uterine leiomyomaTumor Cells CulturedHumansViability assayProspective StudiesCell ProliferationVorinostatbiologyLeiomyomaChemistryCell growthCell CycleObstetrics and GynecologyCell cycleMiddle AgedHDAC3Molecular biologyProliferating cell nuclear antigenExtracellular MatrixGene Expression Regulation NeoplasticHistone Deacetylase InhibitorsReproductive MedicineUterine Neoplasmsbiology.proteinFemaleHistone deacetylaseSignal TransductionFertility and sterility
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Italian Health Care Workers’ Knowledge, Attitudes, and Practices Regarding Human Papillomavirus Infection and Prevention

2020

Objective: To assess healthcare workers&rsquo

AdultMaleHealth Knowledge Attitudes Practicemedicine.medical_specialtyHPVknowledgegenetic structuresHealth PersonnelHealth Toxicology and MutagenesisUterine Cervical Neoplasmslcsh:MedicineScientific literatureimmunizationSettore MED/42 - Igiene Generale E ApplicataArticle03 medical and health sciences0302 clinical medicinepreventionAttitude Awareness Healthcare workers HPV Immunization Knowledge Practice Prevention Sexually transmitted infection Adult Cross-Sectional Studies Female Italy Middle Aged Papillomavirus Vaccines Papillomavirus Infections Uterine Cervical NeoplasmsSurveys and QuestionnairesvaccineIntervention (counseling)Health caremedicineHumansAttitude; Awareness; Healthcare workers; HPV; Immunization; Knowledge; Practice; Prevention; Sexually transmitted infection; VaccineawarenessPapillomavirus Vaccinessexually transmitted infection030212 general & internal medicineHuman papillomavirusbusiness.industryhealthcare workersPapillomavirus Infectionslcsh:RPublic Health Environmental and Occupational HealthMiddle AgedProduct characteristicspracticeCross-Sectional StudiesItaly030220 oncology & carcinogenesisFamily medicineattitudeMulticenter surveyPropensity score matchingFemalebusinessInternational Journal of Environmental Research and Public Health
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Ovarian stimulation does not influence the uterine immune environment in healthy infertile women.

2019

Abstract Research question There is some controversy regarding the impact of ovarian stimulation on immune cells in women undergoing IVF. The study's aim was to determine whether ovarian stimulation affected immune uterine cells in healthy women undergoing IVF. Design This prospective cohort study included 28 patients undergoing IVF and 47 healthy oocyte donors. Endometrial biopsies were taken in a natural cycle and after ovarian stimulation. All participants had a normal karyotype, pelvic ultrasound and cervical cytology results and thyroid-stimulating hormone concentration, as well as normal glucose and insulin concentrations and inherited and acquired thrombophilia test results. Screenin…

AdultNecrosisendocrine system diseasesPopulationStimulationEndometrial biopsies Immune cell populations Natural cycles Ovarian stimulation Peripheral blood natural killer cells Uterine natural killer cellsHuman leukocyte antigenAndrologyImmune systemOvulation InductionmedicineHumansEmbryo ImplantationProspective Studieseducationreproductive and urinary physiologyMenstrual Cycleeducation.field_of_studybusiness.industryUterusObstetrics and GynecologyFOXP3biochemical phenomena metabolism and nutritionfemale genital diseases and pregnancy complicationsKiller Cells NaturalReproductive MedicinebacteriaTumor necrosis factor alphaFemalemedicine.symptombusinessInfertility FemaleDevelopmental BiologyHormoneReproductive biomedicine online
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Laparoscopic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

2015

Abstract Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Federation Internationale de Gynecologie et d'Obstetrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The …

AdultUterine Cervical Neoplasmmedicine.medical_specialtymedicine.medical_treatmentUterine Cervical NeoplasmsHysterectomyPostoperative ComplicationsmedicineRadical hysterectomyHumansProspective StudiesCervical cancer; Laparoscopy; Neoadiuvant chemoradiation; Radical hysterectomy; Adult; Aged; Carcinoma; Squamous Cell; Chemoradiotherapy; Adjuvant; Cisplatin; Feasibility Studies; Female; Humans; Italy; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence; Local; Postoperative Complications; Prospective Studies; Uterine Cervical Neoplasms; Hysterectomy; Laparoscopy; Lymph Node ExcisionRadical surgeryRadical HysterectomyProspective cohort studyNeoadjuvant therapyAgedCervical cancerHysterectomybusiness.industryMedicine (all)Obstetrics and GynecologyLaparoscopic Radical HysterectomyPerioperativeChemoradiotherapy AdjuvantMiddle Agedmedicine.diseaseNeoadjuvant TherapySurgeryFeasibility StudieProspective StudieSettore MED/40 - GINECOLOGIA E OSTETRICIAItalyCervical cancerNeoadiuvant chemoradiationCarcinoma Squamous CellFeasibility StudiesLymph Node ExcisionLymphadenectomyFemaleLaparoscopyPostoperative ComplicationCisplatinNeoplasm Recurrence LocalbusinessHuman
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Successful treatment of a young patient with locally advanced clear cell adenocarcinoma of the uterine cervix undergoing chemoradiation followed by r…

2014

Clear cell adenocarcinoma (CCAC) of the uterine cervix is a rare variant of cervical adenocarcinoma accounting for approximately 4-9% of this disease. Given the rarity of this pathological entity, the optimal treatment management is far from being defined. Earlier evidence suggested that the prognosis of patients bearing cervical CCAC is worse than with other histotypes, thus making the investigation of multimodal treatment strategies clinically worthwhile. Herein, we report the first case of locally advanced, large size cervical CCAC in a young woman who was triaged to concomitant chemoradiotherapy followed by radical surgery and experienced a pathologically assessed optimal response to th…

Adultmedicine.medical_specialtyAdvanced clear cell adenocarcinomaUterine Cervical NeoplasmRadical surgeryUterine Cervical NeoplasmsDisease-Free SurvivalObstetrics and gynaecologyadenocarcinoma uterine cervixUterine cervixmedicineHumansCombined Modality TherapyClear-cell adenocarcinomaRadical surgeryPathologicalSettore MED/08 - ANATOMIA PATOLOGICAbusiness.industryObstetrics and GynecologyMultimodal therapyChemoradiotherapy Adjuvantmedicine.diseaseMultimodal approachCombined Modality TherapyImmunohistochemistryMagnetic Resonance ImagingSurgeryChemoradiationReproductive MedicineAdenocarcinomaFemalebusinessChemoradiotherapyAdenocarcinoma Clear CellHuman
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Laparoscopic temporary clipping of uterine artery during laparoscopic myomectomy

2012

Purpose: Our aim is to study the feasibility and effect of bilateral laparoscopic temporary occlusion of uterine arteries by special vascular clamps on blood loss during laparoscopic myomectomy. Methods: Of 166 women with symptomatic uterine myomas necessitating surgical intervention who wished to retain their uteri, 80 underwent laparoscopic uterine artery clipping and myomectomy (experimental group) and 86 received laparoscopic myomectomy only (control group). Main outcome measures were operating time, number and weight of leiomyomas, blood loss, Doppler examination of the uterine arteries and complications of procedure. Results: In the experimental group the median hemoglobin drop measur…

Adultmedicine.medical_specialtyBlood loTime FactorsTime Factormedicine.medical_treatmentUterusBlood Loss SurgicalLaparoscopic myomectomyLaparoscopic temporary clipping of uterine arteryStatistics NonparametricBlood lossmedicine.arteryUterine MyomectomymedicineUterine NeoplasmHumansSymptomatic myomaUterine arteryLaparoscopyUterine NeoplasmUltrasonographyBlood VolumeChi-Square Distributionmedicine.diagnostic_testLeiomyomabusiness.industryLaparoscopic myomectomyUterusBlood lossObstetrics and GynecologyGeneral MedicineLaparoscopic myomectomy; Laparoscopic temporary clipping of uterine artery; Blood lossMiddle Agedmedicine.diseaseUterine myomectomyHemostasis SurgicalSurgeryUterine Arterymedicine.anatomical_structureLeiomyomaUteruUterine NeoplasmsFemaleLaparoscopybusinessHuman
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